Murine loperamide study data analysis

Scripts used for data analysis in the manuscript "Loperamide increases mouse gut transit time in a dose-dependent manner with treatment duration-dependent effects on distinct gut microbial taxa". The data analysis was performed in R studio (v. 4.3.1). All files in the input folder must be downloaded to perform the analysis.

The aim of this study was to evaluate the effect of different Imolope doses (0, 5, 7.5, and 10 mg/kg) on the mouse intestinal transit time and to investigate the effects of increasing transit time on the gut microbial community. Moreover, in vitro fermentation of mice feces from control animals was performed with and without Imolope in the media to test for direct effects of the drug.